Data Validation through Tissue Analysis

(Author: Stephen Jones | Article Views: 25 | Word Count: 369 | Published: Dec 30th 2007)

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The existing body of literature using Western blot analysis has been primarily defined with data from tumor, immortal, and primary cells growing in vitro. Collectively, results obtained over decades have been integral to the dogma that up- and down-regulation of proteins can be leveraged as Biomarkers of normal development, homeostasis, and disease. However, in contrast to tissues which are composed of multiple cell types, cell lines growing in culture which theoretically consist of clonal populations. Thus, validation or modification of western blot parameters collectively established from decades of cell line data in tissue lysates is key for Biomarker discovery.

IMGENEX can provide you with normal post mortem, cancerous, diseased, and normal adjacent clinical specimens matching your requirements. Custom collection protocols are welcomed. Specimens are available as frozen or formalin-fixed, paraffin-embedded tissue blocks, and include clinical case and detailed pathology reports, as well as final diagnosis and staging. Learn more about this service by visiting our website, or downloading our Tissue Procurement literature.

Related Products
* Tissue Arrays
* Single Tissue Slides
* Tissue & Cell Lysates
* Extraction/ Fractionation Kits
* INSTA-Blot Ready2use WB Membranes

The existing body of literature using Western blot analysis has been primarily defined with data from tumor, immortal, and primary cells growing in vitro. Collectively, results obtained over decades have been integral to the dogma that up- and down-regulation of proteins can be leveraged as Biomarkers of normal development, homeostasis, and disease. However, in contrast to tissues which are composed of multiple cell types, cell lines growing in culture which theoretically consist of clonal populations. Thus, validation or modification of western blot parameters collectively established from decades of cell line data in tissue lysates is key for Biomarker discovery.

IMGENEX can provide you with normal post mortem, cancerous, diseased, and normal adjacent clinical specimens matching your requirements. Custom collection protocols are welcomed. Specimens are available as frozen or formalin-fixed, paraffin-embedded tissue blocks, and include clinical case and detailed pathology reports, as well as final diagnosis and staging. Learn more about this service by visiting our website, or downloading our Tissue Procurement literature.

About the Author

IMGENEX India Pvt Ltd. the only biotech company in Orissa and one of its kinds in Eastern India. IMGENEX India started in Oct as an outsourcing branch of IMGENEX Corporation, San Diego, USA.Find out more information about Tissue Arrays.

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